Biochem/physiol Actions
Primary TargetnAChR
General description
A highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.r>Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.r>Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.r>Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
This product has met the following criteria to qualify for the following awards: